Comprehensive research hub

Heart Health Research

Trials and evidence on heart failure, atrial fibrillation, prevention, procedures and the practical problem of getting effective care into everyday use.

2studies analyzed

2human studies

2randomized trials

0systematic reviews

0animal studies

What this hub covers

Randomized treatment trials
Heart failure and adherence
Rhythm-control procedures
Cardiovascular prevention

Questions we ask

Do benefits improve survival or only a surrogate measurement?
How long was follow-up?
Was the trial powered to detect uncommon harms?

Latest and foundational evidence

Research connected to this topic

Health & Medicine Moderate evidence

Pulsed-field ablation beat antiarrhythmic drugs as initial therapy in persistent AF

Rhythm-control success was higher at one year, but the device procedure still carried risks and industry funding deserves attention.

April 25, 2026Randomized controlled trialNew England Journal of Medicine

Health & Medicine Moderate evidence

Atrial-appendage closure matched anticoagulants on a composite outcome in one trial

The device was noninferior for cardiovascular death, stroke or embolism and reduced non-procedural bleeding over three years.

March 28, 2026Randomized noninferiority trialNew England Journal of Medicine

Research connected to this topic

Pulsed-field ablation beat antiarrhythmic drugs as initial therapy in persistent AF

Atrial-appendage closure matched anticoagulants on a composite outcome in one trial

Explore adjacent research

Metabolism & Obesity Research